Is doxycycline gluten-free?
Looks mostly clean — worth verifying with the maker. Mostly yes — but worth a quick call to the manufacturer for some generics. Of 11 product labels we checked, 8 are clean, 1 are confirmed gluten-free by the maker, and 2 contain an inactive ingredient (typically a source-ambiguous starch) whose botanical origin isn't fully disclosed. None contained confirmed gluten.
Drug context
About doxycycline
Doxycycline is a tetracycline-class antibiotic used for acne, Lyme disease, and respiratory infections, sold under brand names including Vibramycin, Oracea.
Why this matters
Different manufacturers, different ingredients
Generics of doxycycline use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.
The labels
The 11 we checked
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01Mylan manufacturer-attested gluten-free
Listed gluten-free in Plogsted Alpha List (2017-04-28)
View source label → -
02Strides Pharma Science Limited worth a call to confirm
Worth a call to the maker: SODIUM STARCH GLYCOLATE TYPE A
Inactive ingredients FD&C YELLOW NO. 6 · FERRIC OXIDE RED · FERRIC OXIDE YELLOW · HYPROMELLOSE 2910 (5 MPA.S) · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 6000 · SILICON DIOXIDE · SODIUM STARCH GLYCOLATE TYPE A · TALC · TITANIUM DIOXIDE
View source label → -
03Strides Pharma Science Limited worth a call to confirm
Worth a call to the maker: SODIUM STARCH GLYCOLATE TYPE A
Inactive ingredients FD&C YELLOW NO. 6 · FERRIC OXIDE RED · FERRIC OXIDE YELLOW · HYPROMELLOSE 2910 (5 MPA.S) · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 6000 · SILICON DIOXIDE · SODIUM STARCH GLYCOLATE TYPE A · TALC · TITANIUM DIOXIDE
View source label → -
04Chartwell RX, LLC nothing flagged on the label
Inactive ingredients ALCOHOL · CROSCARMELLOSE SODIUM · D&C YELLOW NO. 10 ALUMINUM LAKE · FD&C BLUE NO. 1 · FD&C BLUE NO. 1 ALUMINUM LAKE · FD&C BLUE NO. 2 · FD&C RED NO. 3 · FD&C RED NO. 40 ALUMINUM LAKE · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · GELATIN, UNSPECIFIED · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 8000 · POLYVINYL ALCOHOL, UNSPECIFIED · SHELLAC · SODIUM LAURYL SULFATE · TALC · TITANIUM DIOXIDE
View source label → -
05St. Mary's Medical Park Pharmacy nothing flagged on the label
Inactive ingredients CROSCARMELLOSE SODIUM · FERRIC OXIDE RED · FERRIC OXIDE YELLOW · HYPROMELLOSE 2910 (6 MPA.S) · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 400 · SILICON DIOXIDE · TITANIUM DIOXIDE · WATER
View source label → -
06Slate Run Pharmaceuticals, LLC nothing flagged on the label
Inactive ingredients ASCORBIC ACID · MANNITOL
View source label → -
07Unit Dose Solutions, Inc. nothing flagged on the label
Inactive ingredients ALCOHOL · BUTYL ALCOHOL · D&C YELLOW NO. 10 · FD&C BLUE NO. 1 · FD&C BLUE NO. 2 · FD&C RED NO. 40 · FERROSOFERRIC OXIDE · GELATIN, UNSPECIFIED · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · PROPYLENE GLYCOL · TITANIUM DIOXIDE
View source label → -
08Acella Pharmaceuticals, LLC nothing flagged on the label
Inactive ingredients CROSCARMELLOSE SODIUM · DOCUSATE SODIUM · FD&C BLUE NO. 2 · FD&C YELLOW NO. 6 · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · PROPYLENE GLYCOL · SILICON DIOXIDE · STARCH, PREGELATINIZED CORN · TITANIUM DIOXIDE
View source label → -
09Strides Pharma Science Limited nothing flagged on the label
Inactive ingredients D&C YELLOW NO. 10 ALUMINUM LAKE · FD&C YELLOW NO. 6 · FERRIC OXIDE YELLOW · HYPROMELLOSE 2910 (3 MPA.S) · HYPROMELLOSE, UNSPECIFIED · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 400 · POLYSORBATE 80 · SILICON DIOXIDE · SODIUM STARCH GLYCOLATE TYPE A POTATO · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label → -
10Strides Pharma Science Limited nothing flagged on the label
Inactive ingredients CELLULOSE, MICROCRYSTALLINE · D&C YELLOW NO. 10 · FD&C RED NO. 40 · FD&C YELLOW NO. 6 · FERRIC OXIDE RED · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · GELATIN · MAGNESIUM STEARATE · SILICON DIOXIDE · SODIUM STARCH GLYCOLATE TYPE A POTATO · TITANIUM DIOXIDE
View source label → -
11Sun Pharmaceutical Industries, Inc. nothing flagged on the label
Inactive ingredients ANHYDROUS LACTOSE · CARNAUBA WAX · CROSCARMELLOSE SODIUM · D&C RED NO. 28 · D&C YELLOW NO. 10 · FD&C BLUE NO. 1 · FD&C RED NO. 40 · GELATIN, UNSPECIFIED · HYPROMELLOSE, UNSPECIFIED · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL, UNSPECIFIED · POLYSORBATE 80 · TITANIUM DIOXIDE
View source label →
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Background
What “gluten in a medication” actually means
Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.
The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →
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