Does doxycycline contain wheat or gluten as an excipient?

We cross-check each doxycycline product label against four data sources: DailyMed (FDA Structured Product Labels), the European Medicines Agency centrally-authorised medicines database, the Plogsted curated gluten-free drug list, and the 2024 Mangione et al. pediatric pharmacy NDC analysis. Inactive ingredients are scanned against a 146-entry red-flag dictionary covering wheat, barley, rye, malt, source-ambiguous starches, and FDA gluten-free attestation phrases. At least one manufacturer has formally attested their formulation contains no gluten. Of 11 labels we checked, 1 are confirmed by the maker and 10 show nothing flagged. Confirm the brand or generic on your bottle matches one of the attesting manufacturers below.

Can different manufacturers' generic versions of doxycycline have different gluten status?

Yes. Generics in the United States must use the same active ingredient as the brand, but they are not required to use the same inactive ingredients. Two generics of doxycycline from different manufacturers can use entirely different starch sources, binders, and fillers. A pharmacy may also switch which manufacturer it dispenses between fills without notifying you. Each manufacturer-specific entry below corresponds to a separately-filed product label.

DailyMed checked live · reference data updated August 19, 2026 · 11 product labels screened

Is doxycycline gluten-free?

By Ned Walsch

Founder and maintainer of Gluten Screen

Updated October 13, 2026

Not clinically reviewed — verify with your pharmacist

Confirmed gluten-free by at least one manufacturer. At least one manufacturer has formally attested their formulation contains no gluten. Of 11 labels we checked, 1 are confirmed by the maker and 10 show nothing flagged. Confirm the brand or generic on your bottle matches one of the attesting manufacturers below.

Drug context

About doxycycline

Doxycycline is a tetracycline-class antibiotic used for acne, Lyme disease, and respiratory infections, sold under brand names including Vibramycin, Oracea.

Why this matters

Different manufacturers, different ingredients

Generics of doxycycline use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.

The labels

The 11 we checked

01

Mylan manufacturer-attested gluten-free

Plogsted list · Doxycycline (Mylan, Watson, West-Ward) · label dated 2017-04-28

Listed gluten-free in Plogsted Alpha List (2017-04-28)
View source label →
02

Chartwell RX LLC nothing flagged on the label

US label (DailyMed) · DOXYCYCLINE HYCLATE TABLET, FILM COATED DOXYCYCLINE HYCLATE CAPSULE DOXYCYCLINE POWDER,… · label dated Oct 01, 2026

Inactive ingredients ANHYDROUS LACTOSE · FD&C RED NO. 40 · FD&C YELLOW NO. 6 · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · METHYLCELLULOSE (400 MPA.S) · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL, UNSPECIFIED · SILICON DIOXIDE · SODIUM STARCH GLYCOLATE TYPE A POTATO · STEARIC ACID · TITANIUM DIOXIDE
View source label →
03

Alembic Pharmaceuticals Inc. nothing flagged on the label

US label (DailyMed) · DOXYCYCLINE HYCLATE TABLET, FILM COATED [ALEMBIC PHARMACEUTICALS INC.] · label dated Sep 15, 2026

Inactive ingredients CROSCARMELLOSE SODIUM · FD&C BLUE NO. 2 · FD&C YELLOW NO. 6 · HYDROXYPROPYL CELLULOSE (70000 WAMW) · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 6000 · STARCH, CORN · TITANIUM DIOXIDE
View source label →
04

Apotex Corp. nothing flagged on the label

US label (DailyMed) · DOXYCYCLINE CAPSULE [APOTEX CORP.] · label dated Sep 14, 2026

Inactive ingredients Croscarmellose Sodium · Lactose Monohydrate · METHACRYLIC ACID - METHYL METHACRYLATE COPOLYMER (1:2) · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · MICROCRYSTALLINE CELLULOSE · Magnesium Stearate · SILICON DIOXIDE · Talc · Triethyl Citrate
View source label →
05

Acella Pharmaceuticals, LLC nothing flagged on the label

US label (DailyMed) · DOXYCYCLINE (DOXYCYCLINE HYCLATE) TABLET, COATED [ACELLA PHARMACEUTICALS, LLC] · label dated Aug 20, 2026

Inactive ingredients CROSCARMELLOSE SODIUM · DOCUSATE SODIUM · FD&C BLUE NO. 2 · FD&C YELLOW NO. 6 · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · PROPYLENE GLYCOL · SILICON DIOXIDE · STARCH, PREGELATINIZED CORN · TITANIUM DIOXIDE
View source label →
06

Coupler LLC nothing flagged on the label

US label (DailyMed) · DOXYCYCLINE CAPSULE [COUPLER LLC] · label dated Aug 20, 2026

Inactive ingredients AMMONIA · CELLULOSE, MICROCRYSTALLINE · D&C YELLOW NO. 10 · FD&C BLUE NO. 1 · FD&C RED NO. 3 · FD&C YELLOW NO. 6 · FERRIC OXIDE RED · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · GELATIN · MAGNESIUM STEARATE · POTASSIUM HYDROXIDE · PROPYLENE GLYCOL · SHELLAC · SILICON DIOXIDE · SODIUM LAURYL SULFATE · SODIUM STARCH GLYCOLATE TYPE A POTATO · TITANIUM DIOXIDE
View source label →
07

Avenacy Inc. nothing flagged on the label

US label (DailyMed) · DOXYCYCLINE INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [AVENACY INC.] · label dated Aug 10, 2026

Inactive ingredients ascorbic acid · mannitol
View source label →
08

Lupin Pharmaceuticals, Inc. nothing flagged on the label

US label (DailyMed) · DOXYCYCLINE INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [LUPIN PHARMACEUTICALS, INC.] · label dated Aug 04, 2026

Inactive ingredients ASCORBIC ACID · MANNITOL
View source label →
09

Wellhouse Pharma, LLC nothing flagged on the label

US label (DailyMed) · DOXYCYCLINE CAPSULE [WELLHOUSE PHARMA, LLC] · label dated Jul 27, 2026

Inactive ingredients D&C YELLOW NO. 10 · FD&C BLUE NO. 1 · FD&C BLUE NO. 2 · FD&C RED NO. 40 · FERRIC OXIDE RED · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · SILICON DIOXIDE · SODIUM STARCH GLYCOLATE TYPE A POTATO · TITANIUM DIOXIDE
View source label →
10

Actavis Pharma, Inc. nothing flagged on the label

US label (DailyMed) · DOXYCYCLINE HYCLATE TABLET, DELAYED RELEASE [ACTAVIS PHARMA, INC.] · label dated Jul 24, 2026

Inactive ingredients CROSPOVIDONE · D&C YELLOW NO. 10 ALUMINUM LAKE · HYPROMELLOSE 2910 (5 MPA.S) · HYPROMELLOSE PHTHALATE (24% PHTHALATE, 55 CST) · MAGNESIUM STEARATE · MANNITOL · MICROCRYSTALLINE CELLULOSE · POVIDONE · SILICIFIED MICROCRYSTALLINE CELLULOSE (125 .MICRO.M) · TALC · TRIETHYL CITRATE
View source label →
11

REMEDYREPACK INC. nothing flagged on the label

US label (DailyMed) · DOXYCYCLINE HYCLATE TABLET, FILM COATED [REMEDYREPACK INC.] · label dated Oct 05, 2026

Inactive ingredients CARNAUBA WAX · CROSCARMELLOSE SODIUM · D&C YELLOW NO. 10 · FD&C RED NO. 40 · HYPROMELLOSE, UNSPECIFIED · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL, UNSPECIFIED · POLYSORBATE 80 · TITANIUM DIOXIDE
View source label →

Try it live

Or screen doxycycline right now

DailyMed updates daily and we have ~76 drugs in our static landing pages — for everything else, the live search is faster.

Screen doxycycline live →

Background

What “gluten in a medication” actually means

Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.

The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →

Keep checking