Does aspirin contain wheat or gluten as an excipient?

We cross-check each aspirin product label against four data sources: DailyMed (FDA Structured Product Labels), the European Medicines Agency centrally-authorised medicines database, the Plogsted curated gluten-free drug list, and the 2024 Mangione et al. pediatric pharmacy NDC analysis. Inactive ingredients are scanned against a 146-entry red-flag dictionary covering wheat, barley, rye, malt, source-ambiguous starches, and FDA gluten-free attestation phrases. At least one manufacturer has formally attested their formulation contains no gluten. Of 13 labels we checked, 3 are confirmed by the maker and 10 show nothing flagged. Confirm the brand or generic on your bottle matches one of the attesting manufacturers below.

Can different manufacturers' generic versions of aspirin have different gluten status?

Yes. Generics in the United States must use the same active ingredient as the brand, but they are not required to use the same inactive ingredients. Two generics of aspirin from different manufacturers can use entirely different starch sources, binders, and fillers. A pharmacy may also switch which manufacturer it dispenses between fills without notifying you. Each manufacturer-specific entry below corresponds to a separately-filed product label.

DailyMed checked live · reference data updated August 19, 2026 · 13 product labels screened

Is aspirin gluten-free?

By Ned Walsch

Founder and maintainer of Gluten Screen

Updated October 13, 2026

Not clinically reviewed — verify with your pharmacist

Confirmed gluten-free by at least one manufacturer. At least one manufacturer has formally attested their formulation contains no gluten. Of 13 labels we checked, 3 are confirmed by the maker and 10 show nothing flagged. Confirm the brand or generic on your bottle matches one of the attesting manufacturers below.

Drug context

About aspirin

Aspirin is an NSAID used for pain, fever, inflammation, and low-dose cardiovascular prevention, sold under brand names including Bayer, Bufferin.

Why this matters

Different manufacturers, different ingredients

Generics of aspirin use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.

The labels

The 13 we checked

01

Leiner manufacturer-attested gluten-free

Plogsted list · Aspirin Enteric Coated 325mg (Leiner, Watson) · label dated 2017-04-28

Listed gluten-free in Plogsted Alpha List (2017-04-28)
View source label →
02

Watson manufacturer-attested gluten-free

Plogsted list · Aspirin 81 mg chewable (Watson) · label dated 2017-04-28

Listed gluten-free in Plogsted Alpha List (2017-04-28)
View source label →
03

Perrigo manufacturer-attested gluten-free

Plogsted list · Baby aspirin (Perrigo, Walgreens) · label dated 2017-04-28

Listed gluten-free in Plogsted Alpha List (2017-04-28)
View source label →
04

CVS Pharmacy nothing flagged on the label

US label (DailyMed) · ASPIRIN TABLET, CHEWABLE [CVS PHARMACY] · label dated Oct 09, 2026

Inactive ingredients D&C RED NO. 27 ALUMINUM LAKE · FD&C RED NO. 40 ALUMINUM LAKE · SACCHARIN SODIUM · STARCH, CORN
View source label →
05

Granules India Ltd nothing flagged on the label

US label (DailyMed) · ACETAMINOPHEN, ASPIRIN AND CAFFEINE TABLET [GRANULES INDIA LTD] · label dated Oct 09, 2026

Inactive ingredients CARNAUBA WAX · HYDROXYPROPYL CELLULOSE (110000 WAMW) · HYPROMELLOSE 2910 (6 MPA.S) · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 400 · SODIUM STEARYL FUMARATE · TITANIUM DIOXIDE
View source label →
06

OPMX LLC nothing flagged on the label

US label (DailyMed) · DOLODOL (ACETAMINOPHEN, ASPIRIN, CAFFEINE) TABLET [OPMX LLC] · label dated Oct 08, 2026

Inactive ingredients CROSPOVIDONE · HYPROMELLOSE, UNSPECIFIED · MICROCRYSTALLINE CELLULOSE · POVIDONE · PROPYLENE GLYCOL · SODIUM LAURYL SULFATE · SODIUM STARCH GLYCOLATE TYPE A CORN · STARCH, CORN · STEARIC ACID · TITANIUM DIOXIDE
View source label →
07

Allegiant Health nothing flagged on the label

US label (DailyMed) · HEADACHE RELIEF EXTRA STRENGTH (ACETAMINOPHEN, ASPIRIN AND CAFFEINE) TABLET, FILM COATE… · label dated Oct 08, 2026

Inactive ingredients CROSCARMELLOSE SODIUM · CROSPOVIDONE · HYPROMELLOSE, UNSPECIFIED · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL, UNSPECIFIED · POVIDONE · SILICON DIOXIDE · STARCH, CORN · STEARIC ACID · TITANIUM DIOXIDE
View source label →
08

HealthLife of USA LLC nothing flagged on the label

US label (DailyMed) · EXTRA STRENGTH ASPIRIN 325 MG (ASPIRIN) TABLET, FILM COATED [HEALTHLIFE OF USA LLC] · label dated Oct 06, 2026

Inactive ingredients HYPROMELLOSE, UNSPECIFIED · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL, UNSPECIFIED · POLYVINYL ALCOHOL · POVIDONE · SILICON DIOXIDE · STARCH, CORN · TALC · TITANIUM DIOXIDE
View source label →
09

HealthLife of USA LLC nothing flagged on the label

US label (DailyMed) · ADULT LOW DOSE ASPIRIN 81 MG (ASPIRIN) TABLET, DELAYED RELEASE [HEALTHLIFE OF USA LLC] · label dated Oct 06, 2026

Inactive ingredients CELLULOSE, MICROCRYSTALLINE · CROSCARMELLOSE SODIUM · D&C YELLOW NO. 10 · FERRIC OXIDE YELLOW · LACTOSE · METHACRYLIC ACID - METHYL METHACRYLATE COPOLYMER (1:1) · POLYSORBATE 80 · SILICON DIOXIDE · SODIUM HYDROXIDE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
10

Meijer Distribution, Inc. nothing flagged on the label

US label (DailyMed) · ASPIRIN TABLET, FILM COATED [MEIJER DISTRIBUTION, INC.] · label dated Oct 05, 2026

Inactive ingredients HYPROMELLOSE, UNSPECIFIED · POLYETHYLENE GLYCOL, UNSPECIFIED · PROPYLENE GLYCOL · STARCH, CORN
View source label →
11

Athlete's Needs Inc nothing flagged on the label

US label (DailyMed) · ASPIRIN TABLET [ATHLETE'S NEEDS INC] · label dated Oct 05, 2026

Inactive ingredients STARCH, CORN
View source label →
12

L.N.K. International, Inc. nothing flagged on the label

US label (DailyMed) · BACK AND BODY EXTRA STRENGTH (ASPIRIN, CAFFEINE) TABLET, FILM COATED [L.N.K. INTERNATIO… · label dated Oct 02, 2026

Inactive ingredients HYPROMELLOSE, UNSPECIFIED · MALTODEXTRIN · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL, UNSPECIFIED · SODIUM LAURYL SULFATE · STARCH, CORN
View source label →
13

L.N.K. International, Inc. nothing flagged on the label

US label (DailyMed) · HEADACHE RELIEF (ACETAMINOPHEN, ASPIRIN, CAFFEINE) TABLET, FILM COATED [L.N.K. INTERNAT… · label dated Oct 02, 2026

Inactive ingredients CROSPOVIDONE, UNSPECIFIED · HYPROMELLOSE, UNSPECIFIED · MICROCRYSTALLINE CELLULOSE · POVIDONE, UNSPECIFIED · PROPYLENE GLYCOL · SODIUM LAURYL SULFATE · SODIUM STARCH GLYCOLATE TYPE A POTATO · STARCH, CORN · STEARIC ACID · TITANIUM DIOXIDE
View source label →

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Background

What “gluten in a medication” actually means

Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.

The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →

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