Does aspirin contain wheat or gluten as an excipient?

We cross-check each aspirin product label against four data sources: DailyMed (FDA Structured Product Labels), the European Medicines Agency centrally-authorised medicines database, the Plogsted curated gluten-free drug list, and the 2024 Mangione et al. pediatric pharmacy NDC analysis. Inactive ingredients are scanned against a 146-entry red-flag dictionary covering wheat, barley, rye, malt, source-ambiguous starches, and FDA gluten-free attestation phrases. At least one manufacturer has formally attested their formulation contains no gluten. Of 13 labels we checked, 3 are confirmed by the maker and 10 show nothing flagged. Confirm the brand or generic on your bottle matches one of the attesting manufacturers below.

Can different manufacturers' generic versions of aspirin have different gluten status?

Yes. Generics in the United States must use the same active ingredient as the brand, but they are not required to use the same inactive ingredients. Two generics of aspirin from different manufacturers can use entirely different starch sources, binders, and fillers. A pharmacy may also switch which manufacturer it dispenses between fills without notifying you. Each manufacturer-specific entry below corresponds to a separately-filed product label.

DailyMed checked live · reference data updated May 17, 2026 · 13 product labels screened

Is aspirin gluten-free?

Confirmed gluten-free by at least one manufacturer. At least one manufacturer has formally attested their formulation contains no gluten. Of 13 labels we checked, 3 are confirmed by the maker and 10 show nothing flagged. Confirm the brand or generic on your bottle matches one of the attesting manufacturers below.

Drug context

About aspirin

Aspirin is an NSAID used for pain, fever, inflammation, and low-dose cardiovascular prevention, sold under brand names including Bayer, Bufferin.

Why this matters

Different manufacturers, different ingredients

Generics of aspirin use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.

The labels

The 13 we checked

01

Leiner manufacturer-attested gluten-free

Plogsted list · Aspirin Enteric Coated 325mg (Leiner, Watson) · label dated 2017-04-28

Listed gluten-free in Plogsted Alpha List (2017-04-28)
View source label →
02

Watson manufacturer-attested gluten-free

Plogsted list · Aspirin 81 mg chewable (Watson) · label dated 2017-04-28

Listed gluten-free in Plogsted Alpha List (2017-04-28)
View source label →
03

Perrigo manufacturer-attested gluten-free

Plogsted list · Baby aspirin (Perrigo, Walgreens) · label dated 2017-04-28

Listed gluten-free in Plogsted Alpha List (2017-04-28)
View source label →
04

St. Mary's Medical Park Pharmacy nothing flagged on the label

US label (DailyMed) · ASPIRIN TABLET [ST. MARY'S MEDICAL PARK PHARMACY] · label dated Jul 03, 2026

Inactive ingredients STARCH, CORN
View source label →
05

St. Mary's Medical Park Pharmacy nothing flagged on the label

US label (DailyMed) · ADULT LOW DOSE ENTERIC COATED ASPIRIN (ASPIRIN) TABLET, COATED [ST. MARY'S MEDICAL PARK… · label dated Jul 03, 2026

Inactive ingredients CELLULOSE, MICROCRYSTALLINE · D&C YELLOW NO. 10 · DIMETHICONE · FD&C YELLOW NO. 6 · HYPROMELLOSES · METHACRYLIC ACID · POLYDEXTROSE · POLYETHYLENE GLYCOL, UNSPECIFIED · SHELLAC · SILICON DIOXIDE · SODIUM BICARBONATE · SODIUM LAURYL SULFATE · STARCH, CORN · TALC · TITANIUM DIOXIDE · TRIACETIN · TRIETHYL CITRATE
View source label →
06

St. Mary's Medical Park Pharmacy nothing flagged on the label

US label (DailyMed) · REGULAR STRENGTH ENTERIC COATED ASPIRIN (ASPIRIN) TABLET, COATED [ST. MARY'S MEDICAL PA… · label dated Jul 03, 2026

Inactive ingredients CELLULOSE, MICROCRYSTALLINE · D&C YELLOW NO. 10 · DIMETHICONE · FD&C YELLOW NO. 6 · FERROSOFERRIC OXIDE · HYPROMELLOSES · POLYDEXTROSE · POLYETHYLENE GLYCOL, UNSPECIFIED · POLYVINYL ACETATE PHTHALATE · PROPYLENE GLYCOL · SHELLAC · SILICON DIOXIDE · SODIUM ALGINATE · SODIUM BICARBONATE · STARCH, CORN · STEARIC ACID · TALC · TITANIUM DIOXIDE · TRIACETIN · TRIETHYL CITRATE
View source label →
07

Wal-Mart Stores Inc nothing flagged on the label

US label (DailyMed) · HEADACHE RELIEF EXTRA STRENGTH (ACETAMINOPHEN, ASPIRIN AND CAFFEINE) TABLET, FILM COATE… · label dated Jul 01, 2026

Inactive ingredients CROSPOVIDONE, UNSPECIFIED · HYPROMELLOSE, UNSPECIFIED · MICROCRYSTALLINE CELLULOSE · POVIDONE, UNSPECIFIED · PROPYLENE GLYCOL · SODIUM LAURYL SULFATE · SODIUM STARCH GLYCOLATE TYPE A POTATO · STARCH, CORN · STEARIC ACID · TITANIUM DIOXIDE
View source label →
08

United Natural Foods, Inc. dba UNFI nothing flagged on the label

US label (DailyMed) · HEADACHE RELIEF (ACETAMINOPHEN, ASPIRIN, CAFFEINE) TABLET, FILM COATED [UNITED NATURAL … · label dated Jul 01, 2026

Inactive ingredients CROSPOVIDONE, UNSPECIFIED · HYPROMELLOSE, UNSPECIFIED · MICROCRYSTALLINE CELLULOSE · POVIDONE, UNSPECIFIED · PROPYLENE GLYCOL · SODIUM LAURYL SULFATE · SODIUM STARCH GLYCOLATE TYPE A POTATO · STARCH, CORN · STEARIC ACID · TITANIUM DIOXIDE
View source label →
09

ARMY AND AIR FORCE EXCHANGE SERVICE nothing flagged on the label

US label (DailyMed) · ASPIRIN LOW DOSE (ASPIRIN) TABLET, DELAYED RELEASE [ARMY AND AIR FORCE EXCHANGE SERVICE] · label dated Jun 30, 2026

Inactive ingredients D&C YELLOW NO. 10 · DIMETHICONE · FD&C YELLOW NO. 6 · HYPROMELLOSE, UNSPECIFIED · METHACRYLIC ACID · MICROCRYSTALLINE CELLULOSE · POLYDEXTROSE · POLYETHYLENE GLYCOL, UNSPECIFIED · SHELLAC · SILICON DIOXIDE · SODIUM BICARBONATE · SODIUM LAURYL SULFATE · STARCH, CORN · TALC · TITANIUM DIOXIDE · TRIACETIN · TRIETHYL CITRATE · WATER
View source label →
10

Select Consumer Group nothing flagged on the label

US label (DailyMed) · ALKA-SELTZER ORIGINAL (ANHYDROUS CITRIC ACID, ASPIRIN, AND SODIUM BICARBONATE) TABLET, … · label dated Jun 29, 2026
View source label →
11

Chain Drug Marketing Association, Inc. nothing flagged on the label

US label (DailyMed) · ASPIRIN TABLET, FILM COATED [CHAIN DRUG MARKETING ASSOCIATION, INC.] · label dated Jun 26, 2026

Inactive ingredients HYPROMELLOSE, UNSPECIFIED · POLYETHYLENE GLYCOL, UNSPECIFIED · PROPYLENE GLYCOL · STARCH, CORN
View source label →
12

Walgreen Company nothing flagged on the label

US label (DailyMed) · ASPIRIN REGULAR STRENGTH (ASPIRIN) TABLET, FILM COATED [WALGREEN COMPANY] · label dated Jun 26, 2026

Inactive ingredients HYPROMELLOSE, UNSPECIFIED · POLYETHYLENE GLYCOL, UNSPECIFIED · PROPYLENE GLYCOL · STARCH, CORN
View source label →
13

Topco Associates, LLC nothing flagged on the label

US label (DailyMed) · ASPIRIN TABLET, FILM COATED [TOPCO ASSOCIATES, LLC] · label dated Jun 26, 2026

Inactive ingredients HYPROMELLOSE, UNSPECIFIED · POLYETHYLENE GLYCOL, UNSPECIFIED · PROPYLENE GLYCOL · STARCH, CORN
View source label →

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Background

What “gluten in a medication” actually means

Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.

The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →

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