Is bupropion gluten-free?
Confirmed gluten-free by at least one manufacturer. At least one manufacturer has formally attested their formulation contains no gluten. Of 12 labels we checked, 2 are confirmed by the maker and 10 show nothing flagged. Confirm the brand or generic on your bottle matches one of the attesting manufacturers below.
Drug context
About bupropion
Bupropion is an atypical antidepressant also used for smoking cessation, sold under brand names including Wellbutrin, Zyban.
Why this matters
Different manufacturers, different ingredients
Generics of bupropion use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.
The labels
The 12 we checked
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01Purepac manufacturer-attested gluten-free
Listed gluten-free in Plogsted Alpha List (2017-04-28)
View source label → -
02Watson manufacturer-attested gluten-free
Listed gluten-free in Plogsted Alpha List (2017-04-28)
View source label → -
03Oceanside Pharmaceuticals nothing flagged on the label
Inactive ingredients CARNAUBA WAX · CROSPOVIDONE, UNSPECIFIED · DIBUTYL SEBACATE · ETHYLCELLULOSE, UNSPECIFIED · GLYCERYL DIBEHENATE · POLYETHYLENE GLYCOL, UNSPECIFIED · POLYVINYL ALCOHOL, UNSPECIFIED
View source label → -
04St. Mary's Medical Park Pharmacy nothing flagged on the label
Inactive ingredients CROSPOVIDONE (120 .MU.M) · D&C RED NO. 7 · FUMARIC ACID · HYDROXYPROPYL CELLULOSE (1600000 WAMW) · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · METHYLCELLULOSE (100 MPA.S) · POLYETHYLENE GLYCOL 8000 · SILICON DIOXIDE · TITANIUM DIOXIDE
View source label → -
05Unit Dose Solutions, Inc. nothing flagged on the label
Inactive ingredients ALCOHOL · ETHYLCELLULOSE (100 MPA.S) · FERROSOFERRIC OXIDE · GLYCERYL DIBEHENATE · HYPROMELLOSES · ISOPROPYL ALCOHOL · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · POLYETHYLENE GLYCOL 1450 · POLYVINYL ALCOHOL · POVIDONE K30 · POVIDONE K90 · PROPYLENE GLYCOL · SILICON DIOXIDE · TRIETHYL CITRATE
View source label → -
06Actavis Pharma, Inc. nothing flagged on the label
Inactive ingredients CELLULOSE, MICROCRYSTALLINE · ETHYLCELLULOSES · FERROSOFERRIC OXIDE · HYDROXYPROPYL CELLULOSE (1600000 WAMW) · HYPROMELLOSE 2910 (6 MPA.S) · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · PROPYLENE GLYCOL · SILICON DIOXIDE · STEARIC ACID · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label → -
07Northwind Health Company, LLC nothing flagged on the label
Inactive ingredients AMMONIA · CYSTEINE HYDROCHLORIDE · DIBUTYL SEBACATE · ETHYLCELLULOSES · FERROSOFERRIC OXIDE · GLYCERYL BEHENATE/EICOSADIOATE · HYDROXYPROPYL CELLULOSE, LOW SUBSTITUTED · METHACRYLIC ACID-ETHYL ACRYLATE COPOLYMER (1:1) TYPE A · POLYVINYL ALCOHOL, UNSPECIFIED · POVIDONE · PROPYLENE GLYCOL · SHELLAC · SILICA DIMETHYL SILYLATE · SILICON DIOXIDE · TRIETHYL CITRATE
View source label → -
08Solco Healthcare US LLC nothing flagged on the label
Inactive ingredients CYSTEINE HYDROCHLORIDE · FD&C BLUE NO. 2 · FD&C RED NO. 40 · FERRIC OXIDE RED · FERROSOFERRIC OXIDE · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · TALC · TITANIUM DIOXIDE
View source label → -
09Axsome Therapeutics, Inc. nothing flagged on the label
Inactive ingredients CARBOMER HOMOPOLYMER, UNSPECIFIED TYPE · CROSPOVIDONE · CYSTEINE HYDROCHLORIDE · FERRIC OXIDE RED · FERRIC OXIDE YELLOW · GLYCERYL MONOCAPRYLATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYVINYL ALCOHOL, UNSPECIFIED · SILICON DIOXIDE · SODIUM LAURYL SULFATE · STEARIC ACID · TALC · TITANIUM DIOXIDE
View source label → -
10Amici Pharma, Inc. nothing flagged on the label
Inactive ingredients FD&C BLUE NO. 2--ALUMINUM LAKE · FD&C RED NO. 40 · HYDROCHLORIC ACID · HYPROMELLOSE 2910 (15 MPA.S) · MICROCRYSTALLINE CELLULOSE · POTASSIUM CHLORIDE · STARCH, CORN · STEARIC ACID · TITANIUM DIOXIDE · TRIETHYL CITRATE · WATER
View source label → -
11Quallent Pharmaceuticals Health LLC nothing flagged on the label
Inactive ingredients AMMONIA · CYSTEINE HYDROCHLORIDE · DIBUTYL SEBACATE · ETHYLCELLULOSES · FERROSOFERRIC OXIDE · GLYCERYL BEHENATE/EICOSADIOATE · HYDROXYPROPYL CELLULOSE, LOW SUBSTITUTED · METHACRYLIC ACID-ETHYL ACRYLATE COPOLYMER (1:1) TYPE A · POLYVINYL ALCOHOL, UNSPECIFIED · POVIDONE · PROPYLENE GLYCOL · SHELLAC · SILICA DIMETHYL SILYLATE · SILICON DIOXIDE · TRIETHYL CITRATE
View source label → -
12American Health Packaging nothing flagged on the label
Inactive ingredients HYDROXYPROPYL CELLULOSE (1600000 WAMW) · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL, UNSPECIFIED · SILICON DIOXIDE · STEARIC ACID · TITANIUM DIOXIDE
View source label →
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Background
What “gluten in a medication” actually means
Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.
The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →
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