Does fluoxetine contain wheat or gluten as an excipient?

We cross-check each fluoxetine product label against four data sources: DailyMed (FDA Structured Product Labels), the European Medicines Agency centrally-authorised medicines database, the Plogsted curated gluten-free drug list, and the 2024 Mangione et al. pediatric pharmacy NDC analysis. Inactive ingredients are scanned against a 146-entry red-flag dictionary covering wheat, barley, rye, malt, source-ambiguous starches, and FDA gluten-free attestation phrases. Mostly yes — but worth a quick call to the manufacturer for some generics. Of 11 product labels we checked, 10 are clean, 0 are confirmed gluten-free by the maker, and 1 contain an inactive ingredient (typically a source-ambiguous starch) whose botanical origin isn't fully disclosed. None contained confirmed gluten.

Can different manufacturers' generic versions of fluoxetine have different gluten status?

Yes. Generics in the United States must use the same active ingredient as the brand, but they are not required to use the same inactive ingredients. Two generics of fluoxetine from different manufacturers can use entirely different starch sources, binders, and fillers. A pharmacy may also switch which manufacturer it dispenses between fills without notifying you. Each manufacturer-specific entry below corresponds to a separately-filed product label.

DailyMed checked live · reference data updated May 17, 2026 · 11 product labels screened

Is fluoxetine gluten-free?

Looks mostly clean — worth verifying with the maker. Mostly yes — but worth a quick call to the manufacturer for some generics. Of 11 product labels we checked, 10 are clean, 0 are confirmed gluten-free by the maker, and 1 contain an inactive ingredient (typically a source-ambiguous starch) whose botanical origin isn't fully disclosed. None contained confirmed gluten.

Drug context

About fluoxetine

Fluoxetine is an SSRI antidepressant for depression, OCD, bulimia, and panic disorder, sold under brand names including Prozac.

Why this matters

Different manufacturers, different ingredients

Generics of fluoxetine use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.

The labels

The 11 we checked

01

Barr worth a call to confirm

Plogsted list · Fluoxetine-all strengths/forms (Barr, Par, Sandoz) · label dated 2017-04-28
View source label →
02

Par Health USA, LLC nothing flagged on the label

US label (DailyMed) · FLUOXETINE HYDROCHLORIDE TABLET, COATED [PAR HEALTH USA, LLC] · label dated Jun 26, 2026

Inactive ingredients CELLULOSE, MICROCRYSTALLINE · CROSPOVIDONE · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL, UNSPECIFIED · POLYVINYL ALCOHOL, UNSPECIFIED · SILICON DIOXIDE · STARCH, CORN · TALC · TITANIUM DIOXIDE
View source label →
03

Unit Dose Solutions, Inc. nothing flagged on the label

US label (DailyMed) · FLUOXETINE CAPSULE [UNIT DOSE SOLUTIONS, INC.] · label dated Jun 23, 2026

Inactive ingredients AMMONIA · FD&C BLUE NO. 1 · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · GELATIN, UNSPECIFIED · POTASSIUM HYDROXIDE · PROPYLENE GLYCOL · SHELLAC · SODIUM LAURYL SULFATE · STARCH, CORN · TITANIUM DIOXIDE
View source label →
04

Direct_rx nothing flagged on the label

US label (DailyMed) · FLUOXETINE HCL CAPSULE [DIRECT_RX] · label dated Jun 18, 2026

Inactive ingredients AMMONIA · D&C YELLOW NO. 10 · FD&C BLUE NO. 1 · FERROSOFERRIC OXIDE · GELATIN, UNSPECIFIED · POTASSIUM HYDROXIDE · PROPYLENE GLYCOL · SHELLAC · SILICON DIOXIDE · SODIUM LAURYL SULFATE · STARCH, CORN · TITANIUM DIOXIDE
View source label →
05

Par Health USA, LLC nothing flagged on the label

US label (DailyMed) · FLUOXETINE TABLET, FILM COATED [PAR HEALTH USA, LLC] · label dated Jun 15, 2026

Inactive ingredients CROSPOVIDONE · MAGNESIUM STEARATE · MANNITOL · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 3350 · POLYVINYL ALCOHOL, UNSPECIFIED · SILICON DIOXIDE · STARCH, CORN · TALC · TITANIUM DIOXIDE
View source label →
06

QPharma Inc nothing flagged on the label

US label (DailyMed) · FLUOXETINE CAPSULE [QPHARMA INC] · label dated Jun 10, 2026

Inactive ingredients AMMONIA · FD&C BLUE NO. 1 · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · GELATIN, UNSPECIFIED · POTASSIUM HYDROXIDE · PROPYLENE GLYCOL · SHELLAC · SODIUM LAURYL SULFATE · STARCH, CORN · TITANIUM DIOXIDE
View source label →
07

Coupler LLC nothing flagged on the label

US label (DailyMed) · FLUOXETINE (FLUOXETINE HYDROCHLORIDE) CAPSULE [COUPLER LLC] · label dated Jun 08, 2026

Inactive ingredients AMMONIA · FD&C BLUE NO. 1 · FERROSOFERRIC OXIDE · GELATIN, UNSPECIFIED · POTASSIUM HYDROXIDE · PROPYLENE GLYCOL · SHELLAC · SILICON DIOXIDE · SODIUM LAURYL SULFATE · STARCH, CORN · TITANIUM DIOXIDE
View source label →
08

St. Mary's Medical Park Pharmacy nothing flagged on the label

US label (DailyMed) · FLUOXETINE (FLUOXETINE HYDROCHLORIDE) CAPSULE [ ST. MARY'S MEDICAL PARK PHARMACY] · label dated May 25, 2026

Inactive ingredients AMMONIA · D&C YELLOW NO. 10 · FD&C BLUE NO. 1 · FERROSOFERRIC OXIDE · GELATIN, UNSPECIFIED · POTASSIUM HYDROXIDE · PROPYLENE GLYCOL · SHELLAC · SILICON DIOXIDE · SODIUM LAURYL SULFATE · STARCH, CORN · TITANIUM DIOXIDE
View source label →
09

Teva Pharmaceuticals USA, Inc. nothing flagged on the label

US label (DailyMed) · OLANZAPINE AND FLUOXETINE CAPSULE [TEVA PHARMACEUTICALS USA, INC.] · label dated May 20, 2026

Inactive ingredients D&C RED NO. 28 · D&C YELLOW NO. 10 · D&C YELLOW NO. 10 ALUMINUM LAKE · FD&C BLUE NO. 1 · FD&C BLUE NO. 1 ALUMINUM LAKE · FD&C BLUE NO. 2--ALUMINUM LAKE · FD&C RED NO. 40 · FD&C YELLOW NO. 6 · FERRIC OXIDE RED · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · GELATIN, UNSPECIFIED · MAGNESIUM STEARATE · PROPYLENE GLYCOL · SHELLAC · STARCH, CORN · TITANIUM DIOXIDE
View source label →
10

Northwind Health Company, LLC nothing flagged on the label

US label (DailyMed) · FLUOXETINE CAPSULE [NORTHWIND HEALTH COMPANY, LLC] · label dated May 13, 2026

Inactive ingredients D&C YELLOW NO. 10 ALUMINUM LAKE · FD&C BLUE NO. 1 ALUMINUM LAKE · GELATIN, UNSPECIFIED · MAGNESIUM STEARATE · PROPYLENE GLYCOL · SHELLAC · STARCH, CORN · TITANIUM DIOXIDE
View source label →
11

Northwind Health Company, LLC nothing flagged on the label

US label (DailyMed) · FLUOXETINE CAPSULE [NORTHWIND HEALTH COMPANY, LLC] · label dated May 13, 2026

Inactive ingredients AMMONIA · FD&C BLUE NO. 1 · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · GELATIN, UNSPECIFIED · POTASSIUM HYDROXIDE · PROPYLENE GLYCOL · SHELLAC · SODIUM LAURYL SULFATE · STARCH, CORN · TITANIUM DIOXIDE
View source label →

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Background

What “gluten in a medication” actually means

Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.

The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →

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