Is cyclobenzaprine gluten-free?
Confirmed gluten-free by at least one manufacturer. At least one manufacturer has formally attested their formulation contains no gluten. Of 11 labels we checked, 1 are confirmed by the maker and 10 show nothing flagged. Confirm the brand or generic on your bottle matches one of the attesting manufacturers below.
Drug context
About cyclobenzaprine
Cyclobenzaprine is a skeletal muscle relaxant used for short-term relief of muscle spasm, sold under brand names including Flexeril.
Why this matters
Different manufacturers, different ingredients
Generics of cyclobenzaprine use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.
The labels
The 11 we checked
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01Mylan manufacturer-attested gluten-free
Listed gluten-free in Plogsted Alpha List (2017-04-28)
View source label → -
02Unit Dose Solutions, Inc. nothing flagged on the label
Inactive ingredients ANHYDROUS LACTOSE · CELLULOSE, MICROCRYSTALLINE · CROSPOVIDONE (15 MPA.S AT 5%) · D&C YELLOW NO. 10 · FD&C YELLOW NO. 6 · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL 400 · POLYSORBATE 80 · SILICON DIOXIDE · STARCH, CORN · TITANIUM DIOXIDE
View source label → -
03Tonix Medicines, Inc. nothing flagged on the label
Inactive ingredients CROSPOVIDONE (120 .MU.M) · D&C YELLOW NO. 10 · DIBASIC POTASSIUM PHOSPHATE · Mannitol · SILICON DIOXIDE · SODIUM STEARYL FUMARATE · Starch, Corn
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04Redpharm Drug nothing flagged on the label
Inactive ingredients ANHYDROUS LACTOSE · CROSPOVIDONE (15 MPA.S AT 5%) · D&C YELLOW NO. 10 · FD&C YELLOW NO. 6 · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL 400 · POLYSORBATE 80 · SILICIFIED MICROCRYSTALLINE CELLULOSE (50 .MICRO.M) · STARCH, CORN · TITANIUM DIOXIDE
View source label → -
05TruPharma LLC nothing flagged on the label
Inactive ingredients ANHYDROUS LACTOSE · CELLULOSE, MICROCRYSTALLINE · CROSPOVIDONE (15 MPA.S AT 5%) · D&C YELLOW NO. 10 · FD&C BLUE NO. 2 · FD&C YELLOW NO. 6 · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL 400 · POLYSORBATE 80 · SILICON DIOXIDE · STARCH, CORN · TITANIUM DIOXIDE
View source label → -
06NCS HealthCare of KY, LLC dba Vangard Labs nothing flagged on the label
Inactive ingredients CELLULOSE, MICROCRYSTALLINE · FERRIC OXIDE YELLOW · HYPROMELLOSES · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL 400 · POLYSORBATE 80 · SILICON DIOXIDE · STARCH, CORN · TITANIUM DIOXIDE
View source label → -
07Cipla USA Inc. nothing flagged on the label
Inactive ingredients FERRIC OXIDE RED · FERRIC OXIDE YELLOW · HYPROMELLOSE 2910 (3 MPA.S) · HYPROMELLOSE 2910 (6 MPA.S) · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 400 · POLYSORBATE 80 · SILICON DIOXIDE · STARCH, CORN · TITANIUM DIOXIDE
View source label → -
08St. Mary's Medical Park Pharmacy nothing flagged on the label
Inactive ingredients CROSCARMELLOSE SODIUM · FERRIC OXIDE YELLOW · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE 2910 (15 MPA.S) · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE 102 · SILICON DIOXIDE · TALC · TITANIUM DIOXIDE · TRIACETIN
View source label → -
09Direct_Rx nothing flagged on the label
Inactive ingredients CROSCARMELLOSE SODIUM · FD&C YELLOW NO. 6 · FERRIC OXIDE YELLOW · LACTOSE, UNSPECIFIED FORM · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL, UNSPECIFIED · POLYVINYL ALCOHOL, UNSPECIFIED · SILICON DIOXIDE · TALC · TITANIUM DIOXIDE
View source label → -
10Teva Pharmaceuticals USA, Inc. nothing flagged on the label
Inactive ingredients CALCIUM PHOSPHATE, DIBASIC, ANHYDROUS · CELLULOSE, MICROCRYSTALLINE · CROSCARMELLOSE SODIUM · HYDROXYPROPYL CELLULOSE (1600000 WAMW) · HYPROMELLOSES · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL, UNSPECIFIED · SILICON DIOXIDE · TITANIUM DIOXIDE
View source label → -
11ST. MARY'S MEDICAL PARK PHARMACY nothing flagged on the label
Inactive ingredients ANHYDROUS LACTOSE · CELLULOSE, MICROCRYSTALLINE · CROSPOVIDONE (15 MPA.S AT 5%) · D&C YELLOW NO. 10 · FD&C YELLOW NO. 6 · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL 400 · POLYSORBATE 80 · SILICON DIOXIDE · STARCH, CORN · TITANIUM DIOXIDE
View source label →
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Background
What “gluten in a medication” actually means
Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.
The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →
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