Is metoprolol gluten-free?
Confirmed gluten-free by at least one manufacturer. At least one manufacturer has formally attested their formulation contains no gluten. Of 12 labels we checked, 2 are confirmed by the maker and 10 show nothing flagged. Confirm the brand or generic on your bottle matches one of the attesting manufacturers below.
Drug context
About metoprolol
Metoprolol is a beta blocker used for high blood pressure, chest pain, and after a heart attack, sold under brand names including Lopressor, Toprol-XL.
Why this matters
Different manufacturers, different ingredients
Generics of metoprolol use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.
The labels
The 12 we checked
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01(manufacturer not listed) manufacturer-attested gluten-free
Listed gluten-free in Plogsted Alpha List (2017-04-28)
View source label → -
02Apothecon manufacturer-attested gluten-free
Listed gluten-free in Plogsted Alpha List (2017-04-28)
View source label → -
03Redpharm Drug nothing flagged on the label
Inactive ingredients ACETYLTRIBUTYL CITRATE · CELLULOSE, MICROCRYSTALLINE · CROSCARMELLOSE SODIUM · ETHYLCELLULOSE (10 MPA.S) · HYDROGENATED COTTONSEED OIL · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSES · METHYLENE CHLORIDE · POLYETHYLENE GLYCOL 6000 · SILICON DIOXIDE · SODIUM STEARYL FUMARATE · TALC · TITANIUM DIOXIDE
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04Northwind Health Company, LLC nothing flagged on the label
Inactive ingredients CROSCARMELLOSE SODIUM · D&C RED NO. 30 · HYPROMELLOSE, UNSPECIFIED · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 3350 · POVIDONE K30 · SILICON DIOXIDE · TITANIUM DIOXIDE
View source label → -
05Oneosource Specialty Pharma Limited nothing flagged on the label
Inactive ingredients SODIUM CHLORIDE
View source label → -
06Aphena Pharma Solutions - Tennessee, LLC nothing flagged on the label
Inactive ingredients LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · SILICON DIOXIDE · SODIUM STARCH GLYCOLATE TYPE A POTATO
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07Aphena Pharma Solutions - Tennessee, LLC nothing flagged on the label
Inactive ingredients ACETYLTRIBUTYL CITRATE · CELLULOSE, MICROCRYSTALLINE · CROSCARMELLOSE SODIUM · ETHYLCELLULOSE (10 MPA.S) · HYDROGENATED COTTONSEED OIL · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSES · METHYLENE CHLORIDE · POLYETHYLENE GLYCOL 6000 · SILICON DIOXIDE · SODIUM STEARYL FUMARATE · TALC · TITANIUM DIOXIDE
View source label → -
08BluePoint Laboratories nothing flagged on the label
Inactive ingredients CROSCARMELLOSE SODIUM · ETHYLCELLULOSE (20 MPA.S) · HYPROMELLOSE 2910 (5 MPA.S) · ISOPROPYL ALCOHOL · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · METHYLENE CHLORIDE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 400 · POLYETHYLENE GLYCOL 6000 · POVIDONE, UNSPECIFIED · SILICON DIOXIDE · SODIUM STEARYL FUMARATE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE · WATER
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09Coupler LLC nothing flagged on the label
Inactive ingredients CROSCARMELLOSE SODIUM · ETHYLCELLULOSE, UNSPECIFIED · HYPROMELLOSE, UNSPECIFIED · LACTOSE MONOHYDRATE · LECITHIN, SOYBEAN · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE OXIDE 200000 · POLYVINYL ALCOHOL, UNSPECIFIED · STEARIC ACID · TALC · TITANIUM DIOXIDE
View source label → -
10Coupler LLC nothing flagged on the label
Inactive ingredients ACETYLTRIBUTYL CITRATE · CROSPOVIDONE (15 MPA.S AT 5%) · ETHYLCELLULOSE (10 MPA.S) · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE 2910 (15 MPA.S) · METHYLENE CHLORIDE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 6000 · SILICON DIOXIDE · SODIUM STEARYL FUMARATE · TALC · TITANIUM DIOXIDE
View source label → -
11Coupler LLC nothing flagged on the label
Inactive ingredients ETHYLCELLULOSE, UNSPECIFIED · HYDROXYPROPYL CELLULOSE (1600000 WAMW) · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYDEXTROSE · POLYETHYLENE GLYCOL, UNSPECIFIED · POVIDONE, UNSPECIFIED · TITANIUM DIOXIDE · TRIACETIN · TRIETHYL CITRATE
View source label → -
12REMEDYREPACK INC. nothing flagged on the label
Inactive ingredients CROSCARMELLOSE SODIUM · ETHYLCELLULOSE (20 MPA.S) · HYPROMELLOSE 2910 (5 MPA.S) · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 400 · POLYETHYLENE GLYCOL 6000 · POVIDONE, UNSPECIFIED · SILICON DIOXIDE · SODIUM STEARYL FUMARATE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
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Background
What “gluten in a medication” actually means
Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.
The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →
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