Does metoprolol contain wheat or gluten as an excipient?

We cross-check each metoprolol product label against four data sources: DailyMed (FDA Structured Product Labels), the European Medicines Agency centrally-authorised medicines database, the Plogsted curated gluten-free drug list, and the 2024 Mangione et al. pediatric pharmacy NDC analysis. Inactive ingredients are scanned against a 146-entry red-flag dictionary covering wheat, barley, rye, malt, source-ambiguous starches, and FDA gluten-free attestation phrases. At least one manufacturer has formally attested their formulation contains no gluten. Of 12 labels we checked, 2 are confirmed by the maker and 10 show nothing flagged. Confirm the brand or generic on your bottle matches one of the attesting manufacturers below.

Can different manufacturers' generic versions of metoprolol have different gluten status?

Yes. Generics in the United States must use the same active ingredient as the brand, but they are not required to use the same inactive ingredients. Two generics of metoprolol from different manufacturers can use entirely different starch sources, binders, and fillers. A pharmacy may also switch which manufacturer it dispenses between fills without notifying you. Each manufacturer-specific entry below corresponds to a separately-filed product label.

DailyMed checked live · reference data updated August 19, 2026 · 12 product labels screened

Is metoprolol gluten-free?

By Ned Walsch

Founder and maintainer of Gluten Screen

Updated October 13, 2026

Not clinically reviewed — verify with your pharmacist

Confirmed gluten-free by at least one manufacturer. At least one manufacturer has formally attested their formulation contains no gluten. Of 12 labels we checked, 2 are confirmed by the maker and 10 show nothing flagged. Confirm the brand or generic on your bottle matches one of the attesting manufacturers below.

Drug context

About metoprolol

Metoprolol is a beta blocker used for high blood pressure, chest pain, and after a heart attack, sold under brand names including Lopressor, Toprol-XL.

Why this matters

Different manufacturers, different ingredients

Generics of metoprolol use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.

The labels

The 12 we checked

01

(manufacturer not listed) manufacturer-attested gluten-free

Plogsted list · Metoprolol · label dated 2017-04-28

Listed gluten-free in Plogsted Alpha List (2017-04-28)
View source label →
02

Apothecon manufacturer-attested gluten-free

Plogsted list · Metoprolol (Apothecon, Novapharm) · label dated 2017-04-28

Listed gluten-free in Plogsted Alpha List (2017-04-28)
View source label →
03

Oryza pharmaceuticals Inc. nothing flagged on the label

US label (DailyMed) · METOPROLOL SUCCINATE TABLET, EXTENDED RELEASE [ORYZA PHARMACEUTICALS INC.] · label dated Sep 16, 2026

Inactive ingredients CROSCARMELLOSE SODIUM · ETHYLCELLULOSE, UNSPECIFIED · HYPROMELLOSE, UNSPECIFIED · LACTOSE MONOHYDRATE · LECITHIN, SOYBEAN · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE OXIDE 200000 · POLYVINYL ALCOHOL, UNSPECIFIED · STEARIC ACID · TALC · TITANIUM DIOXIDE
View source label →
04

St. Mary's Medical Park Pharmacy nothing flagged on the label

US label (DailyMed) · METOPROLOL TARTRATE (METOPROLOL) TABLET [ST. MARY'S MEDICAL PARK PHARMACY] · label dated Sep 16, 2026

Inactive ingredients CROSCARMELLOSE SODIUM · D&C RED NO. 30 · HYPROMELLOSE, UNSPECIFIED · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 3350 · POVIDONE K30 · SILICON DIOXIDE · TITANIUM DIOXIDE
View source label →
05

Northwind Health Company, LLC nothing flagged on the label

US label (DailyMed) · METOPROLOL TARTRATE (METOPROLOL) TABLET [NORTHWIND HEALTH COMPANY, LLC] · label dated Sep 07, 2026

Inactive ingredients CROSCARMELLOSE SODIUM · HYPROMELLOSE, UNSPECIFIED · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 3350 · POVIDONE K30 · SILICON DIOXIDE · TITANIUM DIOXIDE
View source label →
06

Granules India Ltd nothing flagged on the label

US label (DailyMed) · METOPROLOL SUCCINATE TABLET, EXTENDED RELEASE [GRANULES INDIA LTD] · label dated Sep 07, 2026

Inactive ingredients CARNAUBA WAX · CROSCARMELLOSE SODIUM · ETHYLCELLULOSE (10 MPA.S) · HYDROXYPROPYL CELLULOSE (110000 WAMW) · HYPROMELLOSE 2910 (6 MPA.S) · MANNITOL · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 400 · POLYETHYLENE GLYCOL 6000 · SILICON DIOXIDE · SODIUM STEARYL FUMARATE · TITANIUM DIOXIDE
View source label →
07

Redpharm Drug nothing flagged on the label

US label (DailyMed) · METOPROLOL SUCCINATE TABLET, FILM COATED, EXTENDED RELEASE [REDPHARM DRUG] · label dated Sep 02, 2026

Inactive ingredients ACETYLTRIBUTYL CITRATE · CELLULOSE, MICROCRYSTALLINE · CROSCARMELLOSE SODIUM · ETHYLCELLULOSE (10 MPA.S) · HYDROGENATED COTTONSEED OIL · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSES · METHYLENE CHLORIDE · POLYETHYLENE GLYCOL 6000 · SILICON DIOXIDE · SODIUM STEARYL FUMARATE · TALC · TITANIUM DIOXIDE
View source label →
08

Redpharm Drug nothing flagged on the label

US label (DailyMed) · METOPROLOL SUCCINATE TABLET, FILM COATED, EXTENDED RELEASE [REDPHARM DRUG] · label dated Aug 27, 2026

Inactive ingredients ACETYLTRIBUTYL CITRATE · CELLULOSE, MICROCRYSTALLINE · CROSCARMELLOSE SODIUM · ETHYLCELLULOSE (10 MPA.S) · HYDROGENATED COTTONSEED OIL · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSES · METHYLENE CHLORIDE · POLYETHYLENE GLYCOL 6000 · SILICON DIOXIDE · SODIUM STEARYL FUMARATE · TALC · TITANIUM DIOXIDE
View source label →
09

Redpharm Drug nothing flagged on the label

US label (DailyMed) · METOPROLOL TARTRATE TABLET [REDPHARM DRUG] · label dated Aug 27, 2026

Inactive ingredients LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · SILICON DIOXIDE · SODIUM STARCH GLYCOLATE TYPE A POTATO
View source label →
10

Redpharm Drug nothing flagged on the label

US label (DailyMed) · METOPROLOL TARTRATE (METOPROLOL) TABLET [REDPHARM DRUG] · label dated Aug 27, 2026

Inactive ingredients CROSCARMELLOSE SODIUM · HYPROMELLOSE, UNSPECIFIED · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 3350 · POVIDONE K30 · SILICON DIOXIDE · TITANIUM DIOXIDE
View source label →
11

Actavis Pharma, Inc. nothing flagged on the label

US label (DailyMed) · METOPROLOL SUCCINATE TABLET, FILM COATED, EXTENDED RELEASE [ACTAVIS PHARMA, INC.] · label dated Aug 19, 2026

Inactive ingredients ACETYLTRIBUTYL CITRATE · CELLULOSE, MICROCRYSTALLINE · CROSPOVIDONE · ETHYLCELLULOSES · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE 2910 (6 MPA.S) · LOW-SUBSTITUTED HYDROXYPROPYL CELLULOSE, UNSPECIFIED · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL 400 · POLYETHYLENE GLYCOL 6000 · POLYETHYLENE GLYCOL 8000 · POLYSORBATE 80 · SILICON DIOXIDE · TALC · TITANIUM DIOXIDE
View source label →
12

Redpharm Drug nothing flagged on the label

US label (DailyMed) · METOPROLOL SUCCINATE TABLET, FILM COATED, EXTENDED RELEASE [REDPHARM DRUG] · label dated Aug 12, 2026

Inactive ingredients ACETYLTRIBUTYL CITRATE · CELLULOSE, MICROCRYSTALLINE · CROSCARMELLOSE SODIUM · ETHYLCELLULOSE (10 MPA.S) · HYDROGENATED COTTONSEED OIL · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSES · METHYLENE CHLORIDE · POLYETHYLENE GLYCOL 6000 · SILICON DIOXIDE · SODIUM STEARYL FUMARATE · TALC · TITANIUM DIOXIDE
View source label →

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Background

What “gluten in a medication” actually means

Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.

The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →

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