Does esomeprazole contain wheat or gluten as an excipient?

We cross-check each esomeprazole product label against four data sources: DailyMed (FDA Structured Product Labels), the European Medicines Agency centrally-authorised medicines database, the Plogsted curated gluten-free drug list, and the 2024 Mangione et al. pediatric pharmacy NDC analysis. Inactive ingredients are scanned against a 146-entry red-flag dictionary covering wheat, barley, rye, malt, source-ambiguous starches, and FDA gluten-free attestation phrases. We checked 11 product labels for esomeprazole and didn't find any ingredients on our gluten red-flag list. Worth noting — this isn't the same as a manufacturer attestation. Formulations can change without notice, and starch sources aren't always disclosed.

Can different manufacturers' generic versions of esomeprazole have different gluten status?

Yes. Generics in the United States must use the same active ingredient as the brand, but they are not required to use the same inactive ingredients. Two generics of esomeprazole from different manufacturers can use entirely different starch sources, binders, and fillers. A pharmacy may also switch which manufacturer it dispenses between fills without notifying you. Each manufacturer-specific entry below corresponds to a separately-filed product label.

DailyMed checked live · reference data updated May 17, 2026 · 11 product labels screened

Is esomeprazole gluten-free?

Nothing on the labels looks like gluten. We checked 11 product labels for esomeprazole and didn't find any ingredients on our gluten red-flag list. Worth noting — this isn't the same as a manufacturer attestation. Formulations can change without notice, and starch sources aren't always disclosed.

Drug context

About esomeprazole

Esomeprazole is a proton-pump inhibitor used for GERD and erosive esophagitis, sold under brand names including Nexium.

Why this matters

Different manufacturers, different ingredients

Generics of esomeprazole use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.

The labels

The 11 we checked

01

H-E-B nothing flagged on the label

US label (DailyMed) · ESOMEPRAZOLE MAGNESIUM CAPSULE, DELAYED RELEASE [H-E-B] · label dated Jul 01, 2026

Inactive ingredients D&C RED NO. 28 · DIMETHICONE, UNSPECIFIED · FD&C BLUE NO. 1 · FD&C RED NO. 40 · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · GELATIN, UNSPECIFIED · GLYCERYL MONOSTEARATE · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · POLYSORBATE 80 · POTASSIUM HYDROXIDE · SHELLAC · SODIUM LAURYL SULFATE · STARCH, CORN · SUCROSE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
02

Graviti Pharmaceuticals Private Limited nothing flagged on the label

US label (DailyMed) · ESOMEPRAZOLE MAGNESIUM CAPSULE, DELAYED RELEASE [GRAVITI PHARMACEUTICALS PRIVATE LIMITED] · label dated Jun 26, 2026

Inactive ingredients FD&C BLUE NO. 2 · GELATIN, UNSPECIFIED · GLYCERYL DISTEARATE · GLYCERYL MONOSTEARATE · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE 2910 (5 MPA.S) · MAGNESIUM STEARATE · METHACRYLIC ACID-ETHYL ACRYLATE COPOLYMER (1:1) TYPE A · POLYSORBATE 80 · RAW SUGAR · TALC · TRIETHYL CITRATE
View source label →
03

Rising Pharma Holdings, Inc. nothing flagged on the label

US label (DailyMed) · ESOMEPRAZOLE MAGNESIUM CAPSULE, DELAYED RELEASE [RISING PHARMA HOLDINGS, INC.] · label dated Jun 26, 2026

Inactive ingredients FD&C BLUE NO. 2 · GELATIN, UNSPECIFIED · GLYCERYL DISTEARATE · GLYCERYL MONOSTEARATE · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · METHACRYLIC ACID-ETHYL ACRYLATE COPOLYMER (1:1) TYPE A · POLYSORBATE 80 · RAW SUGAR · TALC · TRIETHYL CITRATE
View source label →
04

Slate Run Pharmaceuticals, LLC nothing flagged on the label

US label (DailyMed) · ESOMEPRAZOLE SODIUM INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [SLATE RUN PHARMACEUTI… · label dated Jun 24, 2026

Inactive ingredients EDETATE DISODIUM · SODIUM HYDROXIDE
View source label →
05

Ohm Laboratories Inc. nothing flagged on the label

US label (DailyMed) · ESOMEPRAZOLE (ESOMEPRAZOLE MAGNESIUM) CAPSULE, DELAYED RELEASE [OHM LABORATORIES INC.] · label dated Jun 23, 2026

Inactive ingredients FD&C BLUE NO. 1 · FD&C RED NO. 3 · FERROSOFERRIC OXIDE · GELATIN, UNSPECIFIED · GLYCERYL MONO AND DIPALMITOSTEARATE · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE 2910 (5 MPA.S) · MAGNESIUM STEARATE · METHACRYLIC ACID - ETHYL ACRYLATE COPOLYMER (1:1) TYPE A · POLYSORBATE 80 · POTASSIUM HYDROXIDE · PROPYLENE GLYCOL · SHELLAC · STARCH, CORN · SUCROSE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
06

Amazon.com Services LLC nothing flagged on the label

US label (DailyMed) · BASIC CARE ESOMEPRAZOLE MAGNESIUM (ESOMEPRAZOLE) CAPSULE, DELAYED RELEASE [AMAZON.COM S… · label dated Jun 22, 2026

Inactive ingredients ACACIA · D&C YELLOW NO. 10 · FD&C BLUE NO. 1 · FD&C RED NO. 3 · GELATIN, UNSPECIFIED · GLYCERYL MONOSTEARATE · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · MEGLUMINE · MENTHOL, UNSPECIFIED FORM · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · PEPPERMINT OIL · POLYETHYLENE GLYCOL, UNSPECIFIED · POLYSORBATE 80 · SODIUM LAURYL SULFATE · SPEARMINT OIL · SUCRALOSE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
07

Grocery Outlet, Inc. nothing flagged on the label

US label (DailyMed) · 24 HOUR ESOMEPRAZOLE MAGNESIUM (ESOMEPRAZOLE MAGNESIUM) CAPSULE, DELAYED RELEASE [GROCE… · label dated Jun 08, 2026

Inactive ingredients D&C RED NO. 28 · DIMETHICONE · FD&C BLUE NO. 1 · FD&C RED NO. 40 · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · GELATIN · GLYCERYL MONOSTEARATE · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSES · MAGNESIUM STEARATE · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · POLYSORBATE 80 · POTASSIUM HYDROXIDE · SHELLAC · SODIUM LAURYL SULFATE · STARCH, CORN · SUCROSE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
08

Aurohealth LLC nothing flagged on the label

US label (DailyMed) · ESOMEPRAZOLE MAGNESIUM CAPSULE, DELAYED RELEASE [AUROHEALTH LLC] · label dated Jun 08, 2026

Inactive ingredients AMMONIA · FD&C BLUE NO. 1 · FERRIC OXIDE YELLOW · GELATIN, UNSPECIFIED · GLYCERYL MONOSTEARATE · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM CARBONATE · MAGNESIUM OXIDE · METHACRYLIC ACID - ETHYL ACRYLATE COPOLYMER (1:1) TYPE A · POLYSORBATE 80 · PROPYLENE GLYCOL · SHELLAC · SILICON DIOXIDE · SODIUM LAURYL SULFATE · STARCH, CORN · SUCROSE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
09

MARKSANS PHARMA LIMITED nothing flagged on the label

US label (DailyMed) · ESOMEPRAZOLE MAGNESIUM DELAYED-RELEASE 20 MG (OTC) CAPSULE, DELAYED RELEASE ESOMEPRAZOL… · label dated Jun 02, 2026

Inactive ingredients D&C RED NO. 27 ALUMINUM LAKE · D&C RED NO. 28 · DIMETHICONE · FD&C BLUE NO. 1 · FD&C RED NO. 40 · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · GELATIN · GLYCERYL MONOSTEARATE · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · POLYSORBATE 80 · POTASSIUM HYDROXIDE · SHELLAC · SODIUM LAURYL SULFATE · STARCH, CORN · SUCROSE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
10

Doc Rx nothing flagged on the label

US label (DailyMed) · NAPROXEN AND ESOMEPRAZOLE MAGNESIUM TABLET, DELAYED RELEASE [DOC RX] · label dated May 28, 2026

Inactive ingredients AMMONIA · CROSCARMELLOSE SODIUM · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · HYPROMELLOSE 2910 (3 MPA.S) · HYPROMELLOSE 2910 (5 MPA.S) · LACTOSE MONOHYDRATE · MAGNESIUM OXIDE · MAGNESIUM STEARATE · METHACRYLIC ACID - ETHYL ACRYLATE COPOLYMER (1:1) TYPE A · POLOXAMER 188 · POLYETHYLENE GLYCOL 400 · POVIDONE K90 · PROPYLENE GLYCOL · SHELLAC · SILICON DIOXIDE · SODIUM HYDROXIDE · SODIUM LAURYL SULFATE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
11

(manufacturer not listed) nothing flagged on the label

EU label (EMA) · Nexium Control 20 mg gastro-resistant tablets

Inactive ingredients Glycerol monostearate 40-55 · Hydroxypropylcellulose · Hypromellose 2910 (6 mPa·s) · Reddish-brown iron oxide · Yellow iron oxide · Magnesium stearate · Methacrylic acid ethylacrylate copolymer (1:1) dispersion 30 per cent · Cellulose microcrystalline · Synthetic Paraffin · Macrogol 6000 · Polysorbate 80 · Crospovidone (Type A) · Sodium stearyl fumarate · Sugar spheres (sucrose and maize starch) · Talc · Titanium dioxide · triethyl citrate (see section 2, “Nexium Control contains sucrose, sodium”) · Methacrylic acid - ethyl acrylate copolymer (1:1) dispersion 30 per cent · Carmine · Indigo carmine · Gelatin · Erythrosine · Allura red AC · Povidone K-17 · Propylene glycol · Shellac · Sodium hydroxide · Band · hypromellose
View source label →

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Background

What “gluten in a medication” actually means

Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.

The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →

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