Does omeprazole contain wheat or gluten as an excipient?

We cross-check each omeprazole product label against four data sources: DailyMed (FDA Structured Product Labels), the European Medicines Agency centrally-authorised medicines database, the Plogsted curated gluten-free drug list, and the 2024 Mangione et al. pediatric pharmacy NDC analysis. Inactive ingredients are scanned against a 146-entry red-flag dictionary covering wheat, barley, rye, malt, source-ambiguous starches, and FDA gluten-free attestation phrases. We checked 10 product labels for omeprazole and didn't find any ingredients on our gluten red-flag list. Worth noting — this isn't the same as a manufacturer attestation. Formulations can change without notice, and starch sources aren't always disclosed.

Can different manufacturers' generic versions of omeprazole have different gluten status?

Yes. Generics in the United States must use the same active ingredient as the brand, but they are not required to use the same inactive ingredients. Two generics of omeprazole from different manufacturers can use entirely different starch sources, binders, and fillers. A pharmacy may also switch which manufacturer it dispenses between fills without notifying you. Each manufacturer-specific entry below corresponds to a separately-filed product label.

DailyMed checked live · reference data updated May 17, 2026 · 10 product labels screened

Is omeprazole gluten-free?

Nothing on the labels looks like gluten. We checked 10 product labels for omeprazole and didn't find any ingredients on our gluten red-flag list. Worth noting — this isn't the same as a manufacturer attestation. Formulations can change without notice, and starch sources aren't always disclosed.

Drug context

About omeprazole

Omeprazole is a proton-pump inhibitor used for acid reflux and ulcers, sold under brand names including Prilosec.

Why this matters

Different manufacturers, different ingredients

Generics of omeprazole use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.

The labels

The 10 we checked

01

Unit Dose Solutions, Inc. nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE CAPSULE, DELAYED RELEASE [UNIT DOSE SOLUTIONS, INC.] · label dated Jul 02, 2026

Inactive ingredients ANHYDROUS LACTOSE · CETYL ALCOHOL · FD&C BLUE NO. 1 · GELATIN, UNSPECIFIED · HYPROMELLOSE PHTHALATE (31% PHTHALATE, 40 CST) · HYPROMELLOSE, UNSPECIFIED · MANNITOL · SODIUM LAURYL SULFATE · SODIUM PHOSPHATE, DIBASIC, DIHYDRATE · TITANIUM DIOXIDE
View source label →
02

H-E-B nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE DELAYED-RELEASE (OMEPRAZOLE) TABLET, DELAYED RELEASE [H-E-B] · label dated Jul 01, 2026

Inactive ingredients CROSPOVIDONE, UNSPECIFIED · DIMETHICONE, UNSPECIFIED · FERRIC OXIDE RED · GLYCERYL MONOSTEARATE · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 400 · POLYETHYLENE GLYCOL 6000 · POLYSORBATE 80 · SILICON DIOXIDE · SODIUM STEARYL FUMARATE · STARCH, CORN · SUCROSE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
03

St. Mary's Medical Park Pharmacy nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE CAPSULE, DELAYED RELEASE [ST. MARY'S MEDICAL PARK PHARMACY] · label dated Jun 29, 2026

Inactive ingredients D&C RED NO. 28 · FD&C BLUE NO. 1 · FD&C RED NO. 40 · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · GELATIN · GLYCERYL MONOSTEARATE · HYPROMELLOSES · MEGLUMINE · METHACRYLIC ACID - ETHYL ACRYLATE COPOLYMER (1:1) TYPE A · POLOXAMER 407 · POTASSIUM HYDROXIDE · PROPYLENE GLYCOL · RAW SUGAR · SHELLAC · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
04

PLD Acquisitions LLC DBA Avéma Pharma Solutions nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE TABLET, DELAYED RELEASE [PLD ACQUISITIONS LLC DBA AV&EACUTE;MA PHARMA SOLUTI… · label dated Jun 29, 2026

Inactive ingredients ACETYLTRIBUTYL CITRATE · CROSCARMELLOSE SODIUM · DEXTROSE · FD&C BLUE NO. 2 · FD&C RED NO. 40 · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE 2910 (15 MPA.S) · MAGNESIUM STEARATE · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 3350 · POLYETHYLENE GLYCOL 400 · POLYETHYLENE GLYCOL 8000 · POLYVINYL ALCOHOL, UNSPECIFIED · PROPYLENE GLYCOL · SILICON DIOXIDE · STARCH, CORN · SUCROSE · TALC · TITANIUM DIOXIDE · TRIACETIN · TRIETHYL CITRATE
View source label →
05

PLD Acquisitions LLC DBA Avéma Pharma Solutions nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE TABLET, DELAYED RELEASE [PLD ACQUISITIONS LLC DBA AV&EACUTE;MA PHARMA SOLUTI… · label dated Jun 29, 2026

Inactive ingredients ACETYLTRIBUTYL CITRATE · CROSCARMELLOSE SODIUM · DEXTROSE · FD&C BLUE NO. 2 · FD&C RED NO. 40 · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE 2910 (15 MPA.S) · MAGNESIUM STEARATE · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 3350 · POLYETHYLENE GLYCOL 400 · POLYETHYLENE GLYCOL 8000 · POLYVINYL ALCOHOL, UNSPECIFIED · PROPYLENE GLYCOL · SILICON DIOXIDE · STARCH, CORN · SUCROSE · TALC · TITANIUM DIOXIDE · TRIACETIN · TRIETHYL CITRATE
View source label →
06

P & L Development, LLC nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE TABLET, DELAYED RELEASE [P & L DEVELOPMENT, LLC] · label dated Jun 29, 2026

Inactive ingredients ACETYLTRIBUTYL CITRATE · CROSCARMELLOSE SODIUM · DEXTROSE · FD&C BLUE NO. 2 · FD&C RED NO. 40 · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE 2910 (15 MPA.S) · MAGNESIUM STEARATE · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 3350 · POLYETHYLENE GLYCOL 400 · POLYETHYLENE GLYCOL 8000 · POLYSORBATE 80 · POLYVINYL ALCOHOL, UNSPECIFIED · PROPYLENE GLYCOL · SILICON DIOXIDE · STARCH, CORN · SUCRALOSE · SUCROSE · TALC · TITANIUM DIOXIDE · TRIACETIN · TRIETHYL CITRATE
View source label →
07

PLD Acquisitions LLC DBA Avéma Pharma Solutions nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE TABLET, DELAYED RELEASE [PLD ACQUISITIONS LLC DBA AV&EACUTE;MA PHARMA SOLUTI… · label dated Jun 29, 2026

Inactive ingredients ACETYLTRIBUTYL CITRATE · CROSCARMELLOSE SODIUM · FERRIC OXIDE RED · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE 2910 (15 MPA.S) · MAGNESIUM STEARATE · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 3350 · POLYETHYLENE GLYCOL 400 · POLYETHYLENE GLYCOL 8000 · POLYVINYL ALCOHOL, UNSPECIFIED · SILICON DIOXIDE · STARCH, CORN · SUCROSE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
08

St. Mary's Medical Park Pharmacy nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE CAPSULE, DELAYED RELEASE [ST. MARY'S MEDICAL PARK PHARMACY] · label dated Jun 29, 2026

Inactive ingredients AMMONIA · FERROSOFERRIC OXIDE · GELATIN, UNSPECIFIED · HYPROMELLOSE 2910 (15 MPA.S) · MAGNESIUM OXIDE · METHACRYLIC ACID - ETHYL ACRYLATE COPOLYMER (1:1) TYPE A · POTASSIUM HYDROXIDE · POVIDONE K25 · PROPYLENE GLYCOL · SHELLAC · SODIUM LAURYL SULFATE · STARCH, CORN · SUCROSE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
09

PLD Acquisitions LLC DBA Avéma Pharma Solutions nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE TABLET, DELAYED RELEASE [PLD ACQUISITIONS LLC DBA AV&EACUTE;MA PHARMA SOLUTI… · label dated Jun 29, 2026

Inactive ingredients ACETYLTRIBUTYL CITRATE · CROSCARMELLOSE SODIUM · FERRIC OXIDE RED · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE 2910 (15 MPA.S) · MAGNESIUM STEARATE · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 3350 · POLYETHYLENE GLYCOL 400 · POLYETHYLENE GLYCOL 8000 · POLYVINYL ALCOHOL, UNSPECIFIED · SILICON DIOXIDE · STARCH, CORN · SUCROSE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
10

St. Mary's Medical Park Pharmacy nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE CAPSULE, DELAYED RELEASE [ST. MARY'S MEDICAL PARK PHARMACY] · label dated Jun 26, 2026

Inactive ingredients BUTYL ALCOHOL · CROSPOVIDONE · D&C RED NO. 28 · D&C YELLOW NO. 10 ALUMINUM LAKE · FD&C BLUE NO. 1 · FD&C BLUE NO. 1 ALUMINUM LAKE · FD&C BLUE NO. 2--ALUMINUM LAKE · FD&C RED NO. 40 · FD&C YELLOW NO. 6 · FERRIC OXIDE YELLOW · GELATIN · HYPROMELLOSES · MAGNESIUM STEARATE · MANNITOL · MEGLUMINE · METHACRYLIC ACID - ETHYL ACRYLATE COPOLYMER (1:1) TYPE A · POLOXAMER 407 · POVIDONE · PROPYLENE GLYCOL · SHELLAC · SILICON DIOXIDE · SODIUM LAURYL SULFATE · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →

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Background

What “gluten in a medication” actually means

Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.

The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →

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