Does omeprazole contain wheat or gluten as an excipient?

We cross-check each omeprazole product label against four data sources: DailyMed (FDA Structured Product Labels), the European Medicines Agency centrally-authorised medicines database, the Plogsted curated gluten-free drug list, and the 2024 Mangione et al. pediatric pharmacy NDC analysis. Inactive ingredients are scanned against a 146-entry red-flag dictionary covering wheat, barley, rye, malt, source-ambiguous starches, and FDA gluten-free attestation phrases. We checked 10 product labels for omeprazole and didn't find any ingredients on our gluten red-flag list. Worth noting — this isn't the same as a manufacturer attestation. Formulations can change without notice, and starch sources aren't always disclosed.

Can different manufacturers' generic versions of omeprazole have different gluten status?

Yes. Generics in the United States must use the same active ingredient as the brand, but they are not required to use the same inactive ingredients. Two generics of omeprazole from different manufacturers can use entirely different starch sources, binders, and fillers. A pharmacy may also switch which manufacturer it dispenses between fills without notifying you. Each manufacturer-specific entry below corresponds to a separately-filed product label.

DailyMed checked live · reference data updated August 19, 2026 · 10 product labels screened

Is omeprazole gluten-free?

By Ned Walsch

Founder and maintainer of Gluten Screen

Updated August 20, 2026

Not clinically reviewed — verify with your pharmacist

Nothing on the labels looks like gluten. We checked 10 product labels for omeprazole and didn't find any ingredients on our gluten red-flag list. Worth noting — this isn't the same as a manufacturer attestation. Formulations can change without notice, and starch sources aren't always disclosed.

Drug context

About omeprazole

Omeprazole is a proton-pump inhibitor used for acid reflux and ulcers, sold under brand names including Prilosec.

Why this matters

Different manufacturers, different ingredients

Generics of omeprazole use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.

The labels

The 10 we checked

01

Cabinet Health P.B.C. nothing flagged on the label

US label (DailyMed) · GOODMEDS 24HR ACID REDUCER OMEPRAZOLE 20MG (OMEPRAZOLE 20MG) TABLET, DELAYED RELEASE [C… · label dated Aug 17, 2026

Inactive ingredients CELLULOSE, MICROCRYSTALLINE · CROSPOVIDONE (15 MPA.S AT 5%) · FERRIC OXIDE RED · GLYCERYL MONOSTEARATE · HYDROXYPROPYL CELLULOSE (1600000 WAMW) · HYPROMELLOSE 2910 (5 MPA.S) · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · METHACRYLIC ACID-ETHYL ACRYLATE COPOLYMER (1:1) TYPE A · POLYETHYLENE GLYCOL 6000 · POLYSORBATE 80 · SILICON DIOXIDE · SODIUM HYDROXIDE · SODIUM LAURYL SULFATE · STARCH, CORN · SUCROSE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
02

MARKSANS PHARMA LIMITED nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE 20 MG TABLET, DELAYED RELEASE [MARKSANS PHARMA LIMITED] · label dated Aug 07, 2026

Inactive ingredients CROSPOVIDONE · DIMETHICONE, UNSPECIFIED · ETHYL MENTHANE CARBOXAMIDE · FD&C BLUE NO. 2 ALUMINUM LAKE · FD&C RED NO. 40 · GLYCERYL MONOSTEARATE · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · MENTHOL, UNSPECIFIED FORM · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · MICA · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 6000 · POLYSORBATE 80 · PROPYLENE GLYCOL · SACCHARIN SODIUM · SILICON DIOXIDE · SODIUM STEARYL FUMARATE · STARCH, CORN · SUCROSE · TALC · TITANIUM DIOXIDE · TRIACETIN · TRIETHYL CITRATE
View source label →
03

The Procter & Gamble Manufacturing Company nothing flagged on the label

US label (DailyMed) · PRILOSEC OTC (OMEPRAZOLE MAGNESIUM) TABLET, DELAYED RELEASE [THE PROCTER & GAMBLE MANUF… · label dated Jul 31, 2026

Inactive ingredients ACETYL TRIBUTYL CITRATE · CROSCARMELLOSE SODIUM · FERRIC OXIDE RED · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE 2910 (15 MPA.S) · MAGNESIUM STEARATE · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 3350 · POLYETHYLENE GLYCOL 400 · POLYETHYLENE GLYCOL 8000000 · POLYVINYL ALCOHOL · SILICON DIOXIDE · STARCH, CORN · SUCROSE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
04

Chain Drug Marketing Association INC nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE TABLET, DELAYED RELEASE [CHAIN DRUG MARKETING ASSOCIATION INC] · label dated Jul 24, 2026

Inactive ingredients AMMONIA · BUTYL ALCOHOL · CARNAUBA WAX · FERRIC OXIDE RED · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · HYPROMELLOSE ACETATE SUCCINATE 06081224 (3 MM2/S) · HYPROMELLOSES · LACTOSE MONOHYDRATE · MONOETHANOLAMINE · POLYVINYL ALCOHOL · POVIDONE · PROPYLENE GLYCOL · Polyethylene Glycol 3350 · SHELLAC · SODIUM LAURYL SULFATE · SODIUM STARCH GLYCOLATE TYPE A POTATO · SODIUM STEARATE · SODIUM STEARYL FUMARATE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
05

NorthStar Rx LLC nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE CAPSULE, DELAYED RELEASE [NORTHSTAR RX LLC] · label dated Jul 17, 2026

Inactive ingredients D&C Red No. 28 · FD&C Blue No. 1 · FD&C Red No. 40 · FD&C Yellow No. 6 · butyl alcohol · crospovidone · ferric oxide yellow · gelatin · hypromelloses · magnesium stearate · mannitol · meglumine · methacrylic acid - ethyl acrylate copolymer (1:1) type A · poloxamer 407 · povidone · propylene glycol · shellac · silicon dioxide · sodium lauryl sulfate · titanium dioxide · triethyl citrate
View source label →
06

P & L Development, LLC nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE TABLET, DELAYED RELEASE [P & L DEVELOPMENT, LLC] · label dated Jul 15, 2026

Inactive ingredients ACETYLTRIBUTYL CITRATE · CROSCARMELLOSE SODIUM · DEXTROSE · FD&C BLUE NO. 2 · FD&C RED NO. 40 · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE 2910 (15 MPA.S) · MAGNESIUM STEARATE · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 3350 · POLYETHYLENE GLYCOL 400 · POLYETHYLENE GLYCOL 8000 · POLYSORBATE 80 · POLYVINYL ALCOHOL, UNSPECIFIED · PROPYLENE GLYCOL · SILICON DIOXIDE · STARCH, CORN · SUCRALOSE · SUCROSE · TALC · TITANIUM DIOXIDE · TRIACETIN · TRIETHYL CITRATE
View source label →
07

WALMART INC. (see also Equate) nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE TABLET, DELAYED RELEASE [WALMART INC. (SEE ALSO EQUATE)] · label dated Jul 15, 2026

Inactive ingredients ACETYLTRIBUTYL CITRATE · CROSCARMELLOSE SODIUM · DEXTROSE · FD&C BLUE NO. 2 · FD&C RED NO. 40 · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE 2910 (15 MPA.S) · MAGNESIUM STEARATE · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 3350 · POLYETHYLENE GLYCOL 400 · POLYETHYLENE GLYCOL 8000 · POLYSORBATE 80 · POLYVINYL ALCOHOL, UNSPECIFIED · PROPYLENE GLYCOL · SILICON DIOXIDE · STARCH, CORN · SUCRALOSE · SUCROSE · TALC · TITANIUM DIOXIDE · TRIACETIN · TRIETHYL CITRATE
View source label →
08

Lil' Drug Store Products, Inc. nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE, 24/7 LIFE BY 7-ELEVEN (OMEPRAZOLE TABLET, DELAYED RELEASE) TABLET, DELAYED … · label dated Jul 10, 2026

Inactive ingredients ACETYL TRIBUTYL CITRATE · CROSCARMELLOSE SODIUM · FERRIC OXIDE RED · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE 2910 (15 MPA.S) · MAGNESIUM STEARATE · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 3350 · POLYETHYLENE GLYCOL 400 · POLYETHYLENE GLYCOL 8000 · POLYVINYL ALCOHOL, UNSPECIFIED · SILICON DIOXIDE · STARCH, CORN · SUCROSE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
09

American Sales Company nothing flagged on the label

US label (DailyMed) · CAREONE OMEPRAZOLE (OMEPRAZOLE) TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE [AMERICA… · label dated Jul 10, 2026

Inactive ingredients ASCORBIC ACID · CETYL ALCOHOL · CROSPOVIDONE, UNSPECIFIED · DIMETHYLAMINOETHYL METHACRYLATE - BUTYL METHACRYLATE - METHYL METHACRYLATE COPOLYMER · FERRIC OXIDE RED · HYPROMELLOSE, UNSPECIFIED · MANNITOL · MICROCRYSTALLINE CELLULOSE · PROPYLENE GLYCOL · SILICON DIOXIDE · SODIUM STEARATE · SODIUM STEARYL FUMARATE · SORBITOL · SUCRALOSE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
10

L. Perrigo Company nothing flagged on the label

US label (DailyMed) · GOOD SENSE OMEPRAZOLE (OMEPRAZOLE) CAPSULE, DELAYED RELEASE [L. PERRIGO COMPANY] · label dated Jul 08, 2026

Inactive ingredients FD&C YELLOW NO. 6 · FERRIC OXIDE RED · GELATIN, UNSPECIFIED · GLYCERYL MONOSTEARATE · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · MEGLUMINE · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · POLYETHYLENE GLYCOL, UNSPECIFIED · POLYSORBATE 80 · SHELLAC · SODIUM LAURYL SULFATE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →

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Background

What “gluten in a medication” actually means

Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.

The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →

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