Is Vyvanse gluten-free?
Nothing on the labels looks like gluten. We checked 10 product labels for vyvanse and didn't find any ingredients on our gluten red-flag list. Worth noting — this isn't the same as a manufacturer attestation. Formulations can change without notice, and starch sources aren't always disclosed.
Drug context
About Vyvanse
Vyvanse is a brand name for lisdexamfetamine — a prodrug amphetamine used for ADHD and binge eating disorder. The active ingredient is the same across brand and generic versions, but inactive ingredients (excipients) can differ between manufacturers, which is the whole point of this page.
Why this matters
Different manufacturers, different ingredients
Generics of Vyvanse use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.
The labels
The 10 we checked
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01Granules Pharmaceuticals Inc. nothing flagged on the label
Inactive ingredients CROSCARMELLOSE SODIUM · GUAR GUM · MAGNESIUM STEARATE · MANNITOL · MICROCRYSTALLINE CELLULOSE · SILICON DIOXIDE · SUCRALOSE
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02Granules Pharmaceuticals Inc. nothing flagged on the label
Inactive ingredients AMMONIA · CROSCARMELLOSE SODIUM · D&C RED NO. 28 · D&C YELLOW NO. 10 · FD&C BLUE NO. 1 · FD&C RED NO. 3 · FD&C RED NO. 40 · FD&C YELLOW NO. 6 · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · GELATIN · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POTASSIUM HYDROXIDE · PROPYLENE GLYCOL · SHELLAC · TITANIUM DIOXIDE
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03Rhodes Pharmaceuticals LLC nothing flagged on the label
Inactive ingredients CROSCARMELLOSE SODIUM · D&C RED NO. 28 · FD&C BLUE NO. 1 · FD&C RED NO. 3 · FD&C RED NO. 40 · FD&C YELLOW NO. 6 · FERRIC OXIDE RED · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · GELATIN, UNSPECIFIED · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE 102 · POTASSIUM HYDROXIDE · SHELLAC · SILICON DIOXIDE · TITANIUM DIOXIDE
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04Lannett Company, Inc. nothing flagged on the label
Inactive ingredients CROSCARMELLOSE SODIUM · D&C YELLOW NO. 10 · D&C YELLOW NO. 10 ALUMINUM LAKE · FD&C BLUE NO. 1 · FD&C BLUE NO. 1 ALUMINUM LAKE · FD&C BLUE NO. 2 · FD&C BLUE NO. 2--ALUMINUM LAKE · FD&C RED NO. 40 · FERRIC OXIDE RED · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · GELATIN, UNSPECIFIED · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE 102 · MICROCRYSTALLINE CELLULOSE 302 · PROPYLENE GLYCOL · SHELLAC · SILICON DIOXIDE · TITANIUM DIOXIDE
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05Amneal Pharmaceuticals LLC nothing flagged on the label
Inactive ingredients ALCOHOL · AMMONIA · BUTYL ALCOHOL · CELLULOSE, MICROCRYSTALLINE · CROSPOVIDONE · D&C YELLOW NO. 10 · FD&C BLUE NO. 1 · FD&C RED NO. 40 · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · GELATIN · ISOPROPYL ALCOHOL · LACTOSE MONOHYDRATE · POTASSIUM HYDROXIDE · PROPYLENE GLYCOL · SHELLAC · SODIUM LAURYL SULFATE · SODIUM STEARYL FUMARATE · TITANIUM DIOXIDE · WATER
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06Takeda Pharmaceuticals America, Inc. nothing flagged on the label
Inactive ingredients CROSCARMELLOSE SODIUM · FD&C BLUE NO. 1 · FD&C RED NO. 3 · FD&C YELLOW NO. 6 · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · GELATIN, UNSPECIFIED · GUAR GUM · MAGNESIUM STEARATE · MANNITOL · MICROCRYSTALLINE CELLULOSE · SILICON DIOXIDE · SUCRALOSE · TITANIUM DIOXIDE
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07Apotex Corp. nothing flagged on the label
Inactive ingredients Ammonia · Croscarmellose Sodium · Fd&C Blue No. 1 · Fd&C Red No. 3 · Fd&C Yellow No. 6 · Ferric Oxide Yellow · Ferrosoferric Oxide · GELATIN, UNSPECIFIED · MICROCRYSTALLINE CELLULOSE · Magnesium Stearate · Potassium Hydroxide · Propylene Glycol 1,2-Distearate · SILICON DIOXIDE · Shellac · Titanium Dioxide
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08Azurity Pharmaceuticals, Inc. nothing flagged on the label
Inactive ingredients HYDROCHLORIC ACID · METHYLPARABEN SODIUM · PROPYLENE GLYCOL · PROPYLPARABEN · SACCHARIN · SODIUM HYDROXIDE · SODIUM PHOSPHATE, DIBASIC, DIHYDRATE · SODIUM PHOSPHATE, MONOBASIC, DIHYDRATE
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09Teva Pharmaceuticals, Inc. nothing flagged on the label
Inactive ingredients CROSCARMELLOSE SODIUM · D&C RED NO. 28 · D&C YELLOW NO. 10 · FD&C BLUE NO. 1 · FD&C GREEN NO. 3 · FD&C RED NO. 40 · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · GELATIN · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POTASSIUM HYDROXIDE · PROPYLENE GLYCOL · SHELLAC · TITANIUM DIOXIDE
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10SpecGx LLC nothing flagged on the label
Inactive ingredients ALCOHOL · CROSCARMELLOSE SODIUM · FD&C BLUE NO. 1 · FD&C RED NO. 3 · FD&C YELLOW NO. 6 · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · GELATIN, UNSPECIFIED · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · SHELLAC · SILICON DIOXIDE · SODIUM LAURYL SULFATE · TITANIUM DIOXIDE · WATER
View source label →
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Background
What “gluten in a medication” actually means
Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.
The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →
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