Does Zofran contain wheat or gluten as an excipient?

We cross-check each Zofran product label against four data sources: DailyMed (FDA Structured Product Labels), the European Medicines Agency centrally-authorised medicines database, the Plogsted curated gluten-free drug list, and the 2024 Mangione et al. pediatric pharmacy NDC analysis. Inactive ingredients are scanned against a 146-entry red-flag dictionary covering wheat, barley, rye, malt, source-ambiguous starches, and FDA gluten-free attestation phrases. We checked 10 product labels for zofran and didn't find any ingredients on our gluten red-flag list. Worth noting — this isn't the same as a manufacturer attestation. Formulations can change without notice, and starch sources aren't always disclosed.

Can different manufacturers' generic versions of Zofran have different gluten status?

Yes. Generics in the United States must use the same active ingredient as the brand, but they are not required to use the same inactive ingredients. Two generics of Zofran from different manufacturers can use entirely different starch sources, binders, and fillers. A pharmacy may also switch which manufacturer it dispenses between fills without notifying you. Each manufacturer-specific entry below corresponds to a separately-filed product label.

Last verified May 17, 2026 · 10 product labels screened

Is Zofran gluten-free?

Nothing on the labels looks like gluten. We checked 10 product labels for zofran and didn't find any ingredients on our gluten red-flag list. Worth noting — this isn't the same as a manufacturer attestation. Formulations can change without notice, and starch sources aren't always disclosed.

Drug context

About Zofran

Zofran is a brand name for ondansetron — the brand-name antiemetic ondansetron. The active ingredient is the same across brand and generic versions, but inactive ingredients (excipients) can differ between manufacturers, which is the whole point of this page.

Why this matters

Different manufacturers, different ingredients

Generics of Zofran use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.

The labels

The 10 we checked

01

ST. MARY'S MEDICAL PARK PHARMACY nothing flagged on the label

US label (DailyMed) · ONDANSETRON TABLET, ORALLY DISINTEGRATING [ST. MARY'S MEDICAL PARK PHARMACY] · label dated May 04, 2026

Inactive ingredients ASPARTAME · CROSPOVIDONE (120 .MU.M) · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MANNITOL · MICROCRYSTALLINE CELLULOSE · SILICON DIOXIDE
View source label →
02

Sportpharm LLC nothing flagged on the label

US label (DailyMed) · ONDANSETRON HYDROCHLORIDE TABLET, FILM COATED [SPORTPHARM LLC] · label dated Apr 27, 2026

Inactive ingredients ANHYDROUS LACTOSE · FERRIC OXIDE YELLOW · HYPROMELLOSE 2910 (6 MPA.S) · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · STARCH, CORN · TITANIUM DIOXIDE · TRIACETIN
View source label →
03

PAI Holdings, LLC dba PAI Pharma nothing flagged on the label

US label (DailyMed) · ONDANSETRON SOLUTION [PAI HOLDINGS, LLC DBA PAI PHARMA] · label dated Apr 20, 2026

Inactive ingredients ANHYDROUS CITRIC ACID · FRUCTOSE · HYDROXYETHYL CELLULOSE (140 MPA.S AT 5%) · SODIUM BENZOATE · TRISODIUM CITRATE DIHYDRATE · WATER
View source label →
04

Hikma Pharmaceuticals USA Inc. nothing flagged on the label

US label (DailyMed) · ONDANSETRON INJECTION [HIKMA PHARMACEUTICALS USA INC.] · label dated Apr 17, 2026

Inactive ingredients CITRIC ACID MONOHYDRATE · SODIUM CHLORIDE · TRISODIUM CITRATE DIHYDRATE · WATER
View source label →
05

Hikma Pharmaceuticals USA Inc. nothing flagged on the label

US label (DailyMed) · ONDANSETRON INJECTION [HIKMA PHARMACEUTICALS USA INC.] · label dated Apr 17, 2026

Inactive ingredients CITRIC ACID MONOHYDRATE · METHYLPARABEN · PROPYLPARABEN · SODIUM CHLORIDE · TRISODIUM CITRATE DIHYDRATE · WATER
View source label →
06

Sportpharm LLC nothing flagged on the label

US label (DailyMed) · ONDANSETRON INJECTION, SOLUTION [SPORTPHARM LLC] · label dated Apr 16, 2026

Inactive ingredients ANHYDROUS CITRIC ACID · METHYLPARABEN · PROPYLPARABEN · SODIUM CHLORIDE · TRISODIUM CITRATE DIHYDRATE · WATER
View source label →
07

ASCLEMED USA INC. nothing flagged on the label

US label (DailyMed) · ONDANSETRON HYDROCHLORIDE TABLET, FILM COATED [ASCLEMED USA INC.] · label dated Apr 06, 2026

Inactive ingredients ANHYDROUS LACTOSE · HYPROMELLOSE 2910 (6 MPA.S) · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · STARCH, CORN · TITANIUM DIOXIDE · TRIACETIN
View source label →
08

Sportpharm LLC nothing flagged on the label

US label (DailyMed) · ONDANSETRON HYDROCHLORIDE TABLET, FILM COATED [SPORTPHARM LLC] · label dated Apr 06, 2026

Inactive ingredients ANHYDROUS LACTOSE · HYPROMELLOSE 2910 (6 MPA.S) · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · STARCH, CORN · TITANIUM DIOXIDE · TRIACETIN
View source label →
09

HF Acquisition Co LLC, DBA HealthFirst nothing flagged on the label

US label (DailyMed) · ONDANSETRON TABLET, FILM COATED [HF ACQUISITION CO LLC, DBA HEALTHFIRST] · label dated Mar 26, 2026

Inactive ingredients CELLULOSE, MICROCRYSTALLINE · HYPROMELLOSE 2910 (5 MPA.S) · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL, UNSPECIFIED · SILICON DIOXIDE · SODIUM STARCH GLYCOLATE TYPE A POTATO · STARCH, CORN · TITANIUM DIOXIDE
View source label →
10

JVET PHARMACEUTICALS LLC nothing flagged on the label

US label (DailyMed) · ONDANSETRON INJECTION [JVET PHARMACEUTICALS LLC] · label dated Mar 24, 2026

Inactive ingredients CITRIC ACID MONOHYDRATE · METHYLPARABEN · PROPYLPARABEN · SODIUM CHLORIDE · SODIUM CITRATE
View source label →

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Background

What “gluten in a medication” actually means

Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.

The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →

Keep checking

Other drugs people look up

Important. This page is informational. Drug labels can change without notice; a manufacturer attestation is point-in-time, not a warranty. If you have celiac disease and your pharmacy switches manufacturers, re-screen the new label before taking the dispensed product. For a definitive answer, call the manufacturer's medical-information line with the NDC code from your prescription bottle.